The Amstel River serves as sort of a water beltway around central Amsterdam, in sort of a half-circle. A fun run, especially early, is to follow the river around the city, mainly along the S100. There are not water views the whole way, but provides access to some of the city’s main sights. Starting at Central Station (or any point that works for you), run along the canal to the border of Wesrterpark, and the outskirts of the Jordaan area. Ann Frank house off Blooemgracht/S105 at mile 1.7, Rijkemuseum, Van Gogh Museum and the ‘Heineken Experience’ at mile 3. Nice detour at mile 4 where the S100 hits the S112 and you can head left to see Koninklijk Theater Carré and Hermitage Museum. Tropenmuseum at mile 4.5. The last 2 miles skirt the eastern docklands and provide access to the Tropenmuseum of Ethnography, the Verzetsmuseum of WWII Dutch resistance, botanical gardens, Rembrandt House, Maritime Museum, and Science Center.
Add-On: Head inside the beltway and explore the canals!