For those looking for a long off-road run, the Spanish Moss Trail is the best bet in the Beaufort area. The paved, nearly 10-mile path runs from about 1 mile west of the center if Beaufort, heading south toward Port Royal and north to just past the Marine Corps Air Station. It’s a wide, pleasant path with a pleasant canopy and occasional marsh views. The nicest section is south of Beaufort.
It’s very pleasant to run to the trail from the center of Beaufort. Take Bay St., then bear left on Depot Rd. to access the Depot Rd. trailhead.