A must-do running experience on Charleston is the run from downtown over the Arthur Ravenel Bridge to Patriots Point. The bridge connects the Charleston peninsula to Mount Pleasant. Sullivan’s Island, and coastal routes. It looks daunting to run, but there’s a wide, well-protected multi-use path that’s popular with pedestrians and cyclists. The views are great and the 2-mile incline to the top affords some of the only ‘hill’ running in the Low Country!
It’s about 3.5 miles from East Bay St. near the Aquarium across the bridge to Mt. Pleasant Memorial Waterfront Park. For more, you can continue another ~1.5 miles all the way to Patriots Point. It would be nearly 10 miles for the full out and back, though there are transport options allowing for a one-way run.