One of the running highlights in eastern Cincinnati is the Little Miami Scenic Trail. The 78-mile trail, which runs from Springfield to Anderson Township, is the longest trail in the extensive Miami Valley Trails System. The trail passes through numerous small towns, and by fields of corn and soybeans. In summer, many use the trail to access favorite fishing and canoeing spots.

The closest point to the Cincinnati is at the Municipal Airport where it meets the Ohio River Trail. From here, runners can continue northeast as far as Springfield. The trail follows the outline of the Little Miami River (though not always right alongside it), up to Spring Valley, passing through numerous communities. North of Spring Valley, the route follows historic rail corridors and links larger cities such as Xenia and Springfield, through Yellow Springs, to Springfield, which is 26 miles northeast of Dayton.