If in the Mobile area, it’s worth the 1/2 hour drive south to Fairhope to experience a couple runs featuring nice homes, water views, and live oaks. There are two areas we recommend:
Montrose Historic District. A lovely residential area located 17 miles south of Mobile. The centerpiece is Main St., which is a wide road with gracious trees and historic homes set back from the road. There’s a good sidewalk for running. It’s ~2.5 miles, including an 0.5 mile jaunt down Sea Cliff Dr. to Fly Creek Marina to snag some nice water views. You can also enjoy running on some of the side streets off Main St., such as Sibley St.
Fairhope: Scenic Hwy 98. It’s a pleasant run along a nearly 5-mile stretch of this old highway along Mobile Bay from North Beach Park to Point Clear. At North Point Park, there are waterside paths and a pleasant pier with great water views. Then, follow Scenic Hwy 98 south to Orange Street Beach. The road turns inland, but there there are lovely live oaks and nice homes, with a decent sidewalk for running. Thanks to Lauren for the route suggestion!